Riassunto analitico
The type 2 cyclization of the tert-amino effect has been used to synthesise a new unpublished spiro- quinolizine and quinoline compounds. This work has explored the reactivity of two cyclic di-carbonylic acids, the 1.3-Indandione and the Meldrum's acid, for a Knoevenagel condensation that it was designed as part of the synthetic route. The reactions were carried out trough conventional organic procedure and also in microwave conditions, subsequently the stereochemical features (enantio- and diastereo- properties) of the cyclization were investigated by chiral chromatography. The all obtained products have been characterized trough proton and carbon NMR, HPLC, HRMS and elemental analysis
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Abstract
The type 2 cyclization of the tert-amino effect has been used to synthesise a new unpublished spiro- quinolizine and quinoline compounds. This work has explored the reactivity of two cyclic di-carbonylic acids, the 1.3-Indandione and the Meldrum's acid, for a Knoevenagel condensation that it was designed as part of the synthetic route. The reactions were carried out trough conventional organic procedure and also in microwave conditions, subsequently the stereochemical features (enantio- and diastereo- properties) of the cyclization were investigated by chiral chromatography. The all obtained products have been characterized trough proton and carbon NMR, HPLC, HRMS and elemental analysis
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