Riassunto analitico
Introduction.
Preeclampsia is a multifactorial disease, characterized by abnormal vascular response to placentation that is associated with increased systemic vascular resistance, enhanced platelet aggregation, activation of the coagulation system and endothelial dysfunction.. Endothelial disfunction is involved in the pathogenesis of preeclampsia. Endothelial damage triggers a thrombotic microangiopathy with platelet and coagulation factors consumption.Antithrombin (AT) is a glycoprotein involved in both coagulation system and inflammatory processes. AT is the principal inhibitor of thrombin and factor Xa, involved in both extrinsic and intrinsic coagulation pathways.AT normally decreases during the third trimester of pregnancy and falls during postpartum period. In early-onset preeclampsia there are significantly reduced antithrombin levels, probably reflecting increased consumption, impaired liver function and urinary loss. In a previous observational prospective study, we reported that in patients with PE, a progressive reduction of AT values is associated with deteriorating clinical conditions leading to indication to delivery.Our aim is therefore to evaluate the prevalence of low AT levels in our population in order to assess an intervention trial feasibility.
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