|Tipo di tesi||Tesi di laurea magistrale|
|Titolo||Qualità spermatica ed ambiente: approccio big-data|
|Titolo in inglese||Sperm quality and environment: a big data approach|
|Struttura||Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze|
|Corso di studi||MEDICINA E CHIRURGIA (D.M.270/04)|
|Data inizio appello||2017-10-17|
|Disponibilità||Accessibile via web (tutti i file della tesi sono accessibili)|
Background: recentemente è stato proposto un declino della fertilità maschile nei paesi sviluppati, ma la relazione tra infertilità maschile e fattori ambientali è ancora materia di dibattito.
Background: A decline of male fertility in developed countries has been recently proposed, but the relationship between male infertility and environmental factors is still a matter of debate. Objectives: To assess the influence of environmental temperature (T) and air pollution on semen parameters, using a big-data approach. Methods: Semen analyses from 5131 men living in a province of Northern Italy were collected between January 2010 and March 2016. The temperature was recorded on the day of analysis and the 90 days prior to the analysis and the average value of particulate matter (PM) and NO2 in the year of the test. All data were acquired by geocoding patients residential address and the site of environmental factors registration. Results: 5573 semen analyses were collected. Both maximum and minimum T registered on the day of collection were inversely related to total sperm number (p<0.001), non-progressive motility (NPrM) (p<0.005), typical forms (p<0.001). Results were confirmed considering T in the 30 and 60 days before collection, but not in the 90 days before collection. Total sperm number was lower in summer/autumn (p<0.001) and was inversely related with daylight duration (p<0.001), while progressive motility (PrM) and NPrM increased with the amount of daylight hours (p<0.001). PM10 and PM2.5 were inversely related to PrM (p<0.001 and p<0.005) and atypical forms (p<0.001). Conclusions: This is the first evaluation of the relationship between male fertility and environment using a big-data approach. A seasonal change in semen parameters was demonstrated, with a fluctuation related to both T and daylight duration. A negative effect of air pollution on semen quality is suggested, even if prospective studies are needed to find a cause-effect relationship. Such seasonal and environmental associations should be considered when assessing changes of male fertility over time.