|Tipo di tesi||Tesi di laurea magistrale|
|Titolo||Studio di degradazione della Ciprofloxacina in condizioni controllate con HPLC-UV|
|Titolo in inglese||Degradation study of Ciprofloxacin using HPLC-UV under controlled conditions|
|Struttura||Dipartimento di Scienze della Vita|
|Corso di studi||CHIMICA E TECNOLOGIA FARMACEUTICHE (D.M. 270/04)|
|Data inizio appello||2016-07-19|
|Disponibilità||Accesso limitato: si può decidere quali file della tesi rendere accessibili. Disponibilità mixed (scegli questa opzione se vuoi rendere inaccessibili tutti i file della tesi o parte di essi)|
|Data di rilascio||2056-07-19|
Negli ultimi 30 anni l'aumento della popolazione ha portato l'aumento di inquinamento in acqua ambientale, come la ciprofloxacina una antibiotici ad ampio spettro che può essere prodotti la nascita della nuova resistenza batterica a antibiotici.
Abstract: In the last 30 years the increased of population led the increase of pollution in environmental water, like Ciprofloxacin a broad spectrum antibiotics that can be produce the born of new bacterial resistance at antibiotics. Ciprofloxacin is one of the most antibiotics used for aggressive bacterial resistant to other drugs, used in hospital and for serious infections; for that is better that don't arrive in environmental water. This monograph want analyzed the degradation of Ciprofloxacin in controlled conditions like temperature (40°-20°-4°) and solar radiation, and in different type of water (river, sea, STP and Mill-Q) using HPLC-UV. HPLC-UV is a valid methods for identify the presence and the quantity of Ciprofloxacin in the water; but the is not possible correctly identify the concentrations in waste water and in river water without elimination of salt and organic matters because interfere in the peak of Ciprofloxacin in the chromatogram. For identifications of Ciprofloxacin in the water used a wavelength of 280 nm and the retentions time is 3minutes so is better analyzed every sample 5 minutes for be sure that Ciprofloxacin isp analyzed. I used the Acetonitrile and Acid Acetic ( 40:60 v/v) in reverse phase. This experiment lasted during 11 week for temperature in Mill-Q water, and the degradations is not completed, in 4° is the concentration after 11 week is 26,74% ; in 20° the concentration after 11 week is 17,13% ; in 40° the concentration ofter 11 week is 20%. For solar radiation in river and in Mill-Q water is completed, in 2 hours the concentrations respect the concentration initial is 29,42% and is not possible see the peak. In solar radiation in river water the concentration of Ciprofloxacin after 1 hour is 9,13% respect concentration initial. In sea and in STP water is not possible calculate the degradation without elimination of salt and organic matters using HPLC-UV. The results for environment are positive because the degradations in real condition, like river water, is more fast than in Mill-Q water. In this analysis emerge also that he degradation not depend on temperature because inn this different temperature there is no evident changes in the degradation. Should be considered that during the photo-degradation there are phenomena of separations in different metabolite that are not degradable in environment and con rest in the water and could be absorbed by sludge and when this happened is more hard to eliminate the Ciprofloxacin and can damage the ecosystem and from environment arrive from populations that eat products from agricultural that used the water from WWTPs. Sometimes this system are not sufficient for eliminates all compounds in the water, for that the analysis of the water should be continue for discovered and study new system of depuration of the water, and eliminate definitively the drugs in the water.