Riassunto analitico
The resting state networks are intrinsic functional brain networks that exhibit spontaneous synchronized activity in the absence of any stimulus or task. Several studies have described alterations in resting state networks dynamics in epileptic brains, providing significant contributions to our understanding of the underlying pathophysiology and clinical manifestations of epilepsy. Nevertheless, the relationships between the epileptic resting state networks and the response to Antiseizure medications (ASMs) have to be further investigated.
This study aims to analyze this relationship using a simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) approach. Resting state EEG-fMRI data were acquired from a cohort of 27 controls and 134 epileptic patients, out of which 13 were medication-naive, 48 underwent an ASM monotherapy, 40 a dual ASM therapy and 33 were on three or more ASMs. The functional connectivity within resting state networks, particularly the default mode network (DMN) and dorsal attention network (DAN), was analyzed and compared between the four groups.
Preliminary results suggest that anti-seizure medication response may be associated with different patterns of functional connectivity within resting state networks.
These findings highlight the importance of investigating functional connectivity patterns within resting state networks using techniques like EEG-fMRI, as it provides useful information in order to optimize therapeutic outcomes, potentially predict treatment response and personalize therapeutic strategies for epilepsy.
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