Riassunto analitico
Molecular and clinical heterogeneity is increasingly recognized as a common characteristic of
amyotrophic lateral sclerosis. This heterogeneity makes difficult the development of early
diagnosis and effective treatment approaches, as well as the design and testing of new drugs. As
such, stratification of patients into meaningful disease subgroups, with clinical and biological
relevance, may improve disease management and development of effective treatments. To this
regard, transcriptomics is offering a more comprehensive view of the molecular pathways
underlying ALS, helping to differentiate subtypes of patients based on their specific molecular
signatures. In this thesis, we integrated the analysis of RNAs and miRNAs profiles obtained in
motor cortex of control and ALS patients to identify miRNAs that may alter the expression of ALS
related genes and have a critical role in motor neuron disease.
|
