|Tipo di tesi||Tesi di laurea magistrale|
|Titolo||Caratterizzazione termodinamica di self-emulsifying drug delivery systems (SEDDS) destinati alla veicolazione di fenofibrato|
|Titolo in inglese||Thermodynamic characterization of fenofibrate-loaded self-emulsifying drug delivery systems (SEDDS)|
|Struttura||Dipartimento di Scienze della Vita|
|Corso di studi||CHIMICA E TECNOLOGIA FARMACEUTICHE (D.M. 270/04)|
|Data inizio appello||2021-04-14|
|Disponibilità||Accessibile via web (tutti i file della tesi sono accessibili)|
I self-emulsifying drug delivery systems (SEDDS) sono miscele isotropiche di oli, tensioattivi, solventi e co-solventi/tensioattivi, che offrono un’eccellente soluzione per quanto riguarda la somministrazione orale di farmaci scarsamente solubili in acqua che abbiano però una appropriata capacità di dissoluzione in olio.
Self-emulsifying drug delivery systems (SEDDS) are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, which offer an excellent solution for oral administration of poorly water-soluble drugs having an appropriate ability of dissolution in oil. Thanks to Bahloul et al. research works, it has been developed a new approach to rationalize an optimized design for SEDDS. Fenofibrate, a potent lipid-regulating agent, was selected as drug model. The excipients chosen were: extra virgin olive oil, PEG 300, Tween® 80 and Span® 85. Starting from Bahloul et al. studies, it has been underlined the need to deepen the thermodynamic stability of the different excipient formulations, whereas in particular eight SEDDS formulations, selected for their self-emulsification capacity and their effect on increasing in vitro drug release. This needs stems from the fact that not all these formulations present a homogeneous phase at room temperature. The aim of this work was, therefore, to understand why the same excipients in different ratios form both homogeneous and non-homogeneous formulations at 25°C. Thermodynamic studies were carried out principally with differential scanning calorimetry (DSC) technique. Based on results obtained from the different analysis, it was possible to build an explanatory diagram able to explain the behaviour of binary mixtures of excipients between them and, therefore, the behaviour of SEDDS formulations as a whole. From this study it has emerged that the excipients present in SEDDS formulations, form mixtures that collide in one point at a certain temperature. With increasing temperature, the binary mixtures become progressively homogeneous, until reaching a temperature above which there is no more phase separation for all compositions of excipients. It is important to stress that when all excipients meet each other at certain compositions, they reduce the temperature at which they form a homogeneous mixture and so it is possible to see a homogeneous phase also at room temperature. Everything depends on the amount of each component present in the formulation.